1. Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation.
https://www.ncbi.nlm.nih.gov/pubmed/17030382
2. Results Of Clinical Trial On BioCell Collagen For Joint Health Published In The Journal Of Agricultural And Food Chemistry
https://www.biocelltechnology.com/news/results-clinical-trial-biocell-collagen-joint-health-published-journal-agricultural-and-food-ch
“This ingredient has a lower molecular weight than other forms of joint supplements, which appears to be an important reason for its effectiveness,” comments Jerome Stenehjem, MD, School of Medicine, University of California at San Diego, a principle study investigator. “It is possible that nutrients such as those found in this patented supplement may improve the quality of the joint fluid, thereby supporting better joint health.”
3. Phase I dose escalation pharmacokinetic study in healthy volunteers ofresveratrol, a potential cancer chemopreventive agent.
https://www.ncbi.nlm.nih.gov/pubmed/17548692
4. Articular cartilage: structure, injuries and review of management.
https://www.ncbi.nlm.nih.gov/pubmed/17030382
5. Aggrecan, aging and assembly in articular cartilage.
https://www.ncbi.nlm.nih.gov/pubmed/17030382
6. Effects of oral administration of type II collagen on rheumatoid arthritis.
https://www.ncbi.nlm.nih.gov/pubmed?term=Trentham%20et%20al.%201993%2C%20Science%2C%20pp.%20261%3A%201727-1730
7. Suppression of type II collagen-induced arthritis by the intravenous administration of type II collagen or its constituent peptide alpha 1 (II) CB10.
https://www.ncbi.nlm.nih.gov/pubmed?term=Englert%20et%20al.%201984%2C%20Cell%20Immuno%2C%20pp.%2087%3A%20357-365
8. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature.
https://www.ncbi.nlm.nih.gov/pubmed?term=Bello%20et%20al.%202006%2C%20Curr%20Med%20Res%20Opin%2C%20pp.%2022%2811%29%3A%202221-2232
9. Hyaluronan synthesis and degradation in cartilage and bone.
https://www.ncbi.nlm.nih.gov/pubmed?term=Englert%20et%20al.%201984%2C%20Cell%20Immuno%2C%20pp.%2087%3A%20357-365
10. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen.
https://www.ncbi.nlm.nih.gov/pubmed/12658447
11. Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
https://www.ncbi.nlm.nih.gov/pubmed?term=Loeser%20et%20al.%202002%2C%20Arthritis%20Rheum%2C%20pp.%2046%3A%202349-2357
12. Oxidants, oxidative stress and the biology of aging.
https://www.ncbi.nlm.nih.gov/pubmed?term=Finkel%20et%20al.%202000%2C%20Nature%2C%20pp.%20408%3A%20239-247
13. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function.
https://www.ncbi.nlm.nih.gov/pubmed?term=Yudoh%20et%20al.%202005%2C%20Arthritis%20Res%20Ther%2C%20pp.%207%3A%20R380-R391
14. Telomere Erosion and Senescence in Human Articular Cartilage Chondrocytes
https://academic.oup.com/biomedgerontology/article/56/4/B172/619952
15. Aging and osteoarthritis: the role of chondrocyte senescence and agingchanges in the cartilage matrix.
https://www.ncbi.nlm.nih.gov/pubmed/19303469
16. Hyaluronic acid in cutaneous intrinsic aging.
17. Hyaluronan catabolism: a new metabolic pathway.
https://www.ncbi.nlm.nih.gov/pubmed?term=.%20Stern%20et%20al.%20Hyaluronan%20catabolism%3A%20a%20new%20metabolic%20pathway.%20Eur%20J%20Cell%20Biol.%202004%2C%20Vols.%2083%287%29%3A%20317-325
18. Wiest et al. Native hyaluronic acid indermatology
-results of an expert meeting. J Dtsch Dermatol Ges. 2008,Vols. 6(3): 176-180.
19. Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.
20. Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases.
https://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20ultraviolet%20B%20irradiation%20causes%20loss%20of%20hyaluronic%20acid%20from%20mouse%20dermis%20because%20of%20down-regulation%20of%20hyaluronic%20acid%20syntheisis.%20Dai%20et%20al.%202007%2C%20Am%20J%20Path%2C%20pp.%20282%3A%201451-1561
21. Hyaluronan facilitates transforming growth factor-beta1-mediatedfibroblast proliferation.
22. Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction.
https://www.ncbi.nlm.nih.gov/pubmed/21454519
23. Aging: A Theory Based on Free Radical and Radiation Chemistry
https://academic.oup.com/geronj/article-abstract/11/3/298/616585?redirectedFrom=fulltext
24. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin.
https://www.ncbi.nlm.nih.gov/pubmed?term=Enzymatic%20and%20nonenzymatic%20antioxidants%20in%20epidermis%20and%20dermis%20of%20human%20skin.%20Shindo%20et%20al.1994%2C%20J%20Invest%20Dermatol%2C%20pp.%20102%281%29%3A%20122-124
25. Intake of flavonols and flavones and risk of coronary heart disease in male smokers.
https://www.ncbi.nlm.nih.gov/pubmed/18174158
26. In vivo exposure to ozone depletes vitamins C and E and induces lipid peroxidation in epidermal layers of murine skin.
https://www.ncbi.nlm.nih.gov/pubmed/9214574
27. Ascorbic acid specifically increases type I and type III procollagenmessenger RNA levels in human skin fibroblast.
https://www.ncbi.nlm.nih.gov/pubmed/3351329
28. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing.
https://www.ncbi.nlm.nih.gov/pubmed/11052704
29. Studies on antioxidant activity of pomegranate (Punica granatum) peelextract using in vivo models.
https://www.ncbi.nlm.nih.gov/pubmed/12166961
30. Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermalkeratinocytes.
https://www.ncbi.nlm.nih.gov/pubmed/16613491
31. Bog blueberry anthocyanins alleviate photoaging in ultraviolet-Birradiation-induced human dermal fibroblasts.
https://www.ncbi.nlm.nih.gov/pubmed/19199288
32. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin.
33. Chemoprevention of skin cancer by grape constituent resveratrol:relevance to human disease?
https://www.ncbi.nlm.nih.gov/pubmed/15837718
34. Resveratrol: a multitargeted agent for age-associated chronic diseases.
https://www.ncbi.nlm.nih.gov/pubmed/18414053
35. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.
https://www.ncbi.nlm.nih.gov/pubmed/18523577
36. Ingestion of BioCell Collagen(®), a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs.
https://pubs.acs.org/doi/pdf/10.1021/jf205295u
